Description

Deoxythymidylyl-3'-5'-Deoxyadenylate is a defined dinucleotide, a crucial building block in nucleic acid research and synthesis. This compound serves as a vital reference standard and synthetic intermediate for studying DNA structure, function, and enzymatic processes. It is essential for researchers and manufacturers in the fields of pharmaceutical development, molecular diagnostics, and biotechnology, where precise oligonucleotide components are required.

Application

• Oligonucleotide Synthesis: As a protected dinucleotide phosphoramidite or solid-phase synthesis intermediate.
• Biochemical Research: Used as a substrate or standard in enzymatic studies involving DNA polymerases, ligases, and nucleases.
• Pharmaceutical Development: A key intermediate in the research and production of antisense oligonucleotides, siRNA, and other therapeutic nucleic acids.
• Diagnostic Probe Development: Employed in the design and manufacture of specific DNA probes for genetic testing and molecular diagnostics.
• Academic Research: Fundamental studies on DNA hybridization kinetics, stability, and molecular recognition events.

Basic Information

Product Name	Deoxythymidylyl-3'-5'-Deoxyadenylate
CAS No.	2147-15-1
Molecular Formula	C25H31N8O14P2
Molecular Weight	753.52 g/mol
Synonyms	d(TpA); TpdeA; Thymidylyl-3',5'-deoxyadenosine; Deoxythymidylyl-(3'→5')-deoxyadenosine; 5'-d(TpA)-3'; dTpdA; Deoxythymidine 5'-(3'-deoxyadenylyl) phosphate; T-A Dinucleotide
EINECS	Contact for details

Quality Control

Our Deoxythymidylyl-3'-5'-Deoxyadenylate is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Quality is verified through advanced analytical techniques including HPLC, mass spectrometry, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.