Description

Rac-2-Hydroxy Nicotine is a chiral derivative of nicotine, a key alkaloid, with the CAS registry number 2055-24-5. This compound is significant as a versatile intermediate and reference standard in advanced chemical synthesis and analytical research. It is primarily required by pharmaceutical R&D laboratories, agrochemical developers, and analytical service providers for applications in metabolite studies, chiral resolution, and the development of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel nicotine analogs and potential therapeutic agents targeting neurological pathways.
• Metabolite Reference Standard: Used as an analytical standard in HPLC, LC-MS, and GC-MS for the identification and quantification of nicotine metabolites in pharmacokinetic and toxicological studies.
• Chiral Chemistry Research: Employed in studies of stereoselective synthesis and enzymatic transformations due to its chiral center, aiding in the development of enantioselective processes.
• Agrochemical Development: Acts as a precursor or model compound in the research and development of next-generation plant protection agents and insecticide chemistry.
• Biochemical Research: Utilized in receptor-binding assays and studies investigating the interaction of nicotine derivatives with nicotinic acetylcholine receptors (nAChRs).
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting fundamental research in organic chemistry, pharmacology, and analytical method development.

Basic Information

Item	Detail
Product Name	Rac-2-Hydroxy Nicotine
CAS No.	2055-24-5
Molecular Formula	C₁₀H₁₄N₂O
Molecular Weight	178.23 g/mol
Synonyms	(±)-2-Hydroxynicotine; 2-Hydroxynicotine (racemic); DL-2-Hydroxynicotine; rac-2'-Hydroxynicotine; 1-Methyl-2-(3-pyridyl)-5-hydroxypyrrolidine; Nicotine, 2-hydroxy- (racemic form); 3-[(5-Hydroxy-1-methyl-2-pyrrolidinyl)methyl]pyridine
EINECS	Contact for details

Quality Control

Our Rac-2-Hydroxy Nicotine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity determination by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.