Description

H-D-Phe-Amc·Hcl is a protected amino acid derivative, specifically the hydrochloride salt of H-D-Phenylalanine amide. This high-purity chiral building block is critical for the synthesis of complex peptides and peptidomimetics, where precise stereochemistry and functional group protection are paramount. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic peptides and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected D-phenylalanine residue.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and proteomics research.
• Chemical Biology: Employed in the design and synthesis of activity-based probes and molecular tools for studying biological systems.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for peptide-based Active Pharmaceutical Ingredients (APIs).
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	H-D-Phe-Amc·Hcl
CAS No.	1998700-96-1
Molecular Formula	C10H15ClN2O
Molecular Weight	214.69 g/mol
Synonyms	H-D-Phenylalanine amide hydrochloride; (R)-2-Amino-3-phenylpropanamide hydrochloride; D-Phenylalaninamide hydrochloride; D-Phe-NH2·HCl; Amc-D-Phe-OH·HCl; Boc-D-Phe-amide deprotected HCl salt; Fmoc-D-Phe-amide deprotected HCl salt
EINECS	Contact for details

Quality Control

Our H-D-Phe-Amc·Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via IR and NMR. We provide Certificates of Analysis (COA) with detailed specifications for trace metals, residual solvents, and related substances, ensuring compliance with research and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.