Description

Mal-Peg4-Val-Cit-Pab CAS NO 1949793-41-2 is a specialized, heterobifunctional crosslinker and cleavable linker used in advanced bioconjugation and drug delivery system development. Its core value lies in its precise structure, which incorporates a maleimide group for thiol conjugation, a protease-cleavable valine-citrulline dipeptide sequence, and a self-immolative para-aminobenzyloxycarbonyl (PAB) spacer, enabling the construction of targeted, stimulus-responsive therapeutic agents. This compound is essential for researchers and manufacturers in pharmaceutical R&D, bioconjugation services, and ADC (Antibody-Drug Conjugate) production, where controlled drug release and site-specific labeling are critical.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Construction: Serves as a key component for attaching cytotoxic drugs to monoclonal antibodies via a cleavable linker system.
• Protease-Activated Prodrug Development: Used in the design of prodrugs that release active therapeutic agents specifically in tumor microenvironments with high protease activity.
• Site-Specific Protein and Peptide Modification: Enables controlled, covalent attachment of probes, tags, or other molecules to cysteine residues on biomolecules.
• Controlled-Release Nanocarrier Functionalization: Incorporated into liposomes, polymersomes, or other nanoparticles to create stimulus-responsive drug delivery platforms.
• Diagnostic Agent Conjugation: Facilitates the linking of imaging agents (e.g., fluorophores, radionuclides) to targeting vectors like antibodies or peptides.
• Chemical Biology Tool Development: Employed in research to study enzyme activity, protein interactions, and intracellular trafficking via cleavable linkages.

Basic Information

Product Name	Mal-Peg4-Val-Cit-Pab
CAS No.	1949793-41-2
Molecular Formula	C41H62N6O15
Molecular Weight	878.96 g/mol
Synonyms	Maleimide-PEG4-Valine-Citrulline-PAB; MC-Val-Cit-PAB-PEG4-Mal; N-(3-Maleimidopropionyl)-PEG4-Val-Cit-PAB; Valine-Citrulline-PAB-PEG4-Maleimide; Cleavable ADC Linker Maleimide-PEG4-VC-PAB; VC-PAB-PEG4-MAL; (2S)-2-[[(2S)-5-Amino-2-[[4-[[2-[2-[2-[2-[3-(2,5-Dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]methoxycarbonylamino]pentanoyl]amino]-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Every batch of Mal-Peg4-Val-Cit-Pab is manufactured and analyzed under strict quality management protocols to ensure the high purity and consistency required for sensitive bioconjugation applications. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to confirm identity, purity, and absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.