Description

m-Peg3-Sulfone-Peg3-Acid CAS NO 1919045-04-7 is a heterobifunctional polyethylene glycol (PEG) linker featuring a sulfone group and a terminal carboxylic acid, designed for advanced bioconjugation and cross-linking applications. This compound is engineered to provide a reactive handle for creating stable, functionalized biomolecules and materials with precise control over spacing and solubility. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science, where reliable, high-purity linkers are critical for success.

Application

• ADC (Antibody-Drug Conjugate) Development: As a key linker component for attaching cytotoxic payloads to monoclonal antibodies via its sulfone and carboxylic acid functionalities.
• Protein and Peptide Modification: For site-specific PEGylation to enhance pharmacokinetic properties such as solubility, stability, and circulation half-life.
• Biomaterial Functionalization: Cross-linking agent for modifying surfaces of hydrogels, nanoparticles, and diagnostic devices to introduce bioactive molecules.
• Proteomics Research: Used in the synthesis of activity-based probes (ABPs) or affinity tags for studying enzyme function and protein interactions.
• Diagnostic Reagent Synthesis: Building block for creating conjugates used in immunoassays, biosensors, and imaging agents.
• Polymer Chemistry: Serves as a monomer or chain extender in the synthesis of functional, biodegradable, or stimuli-responsive polymers.

Basic Information

Item	Detail
Product Name	m-Peg3-Sulfone-Peg3-Acid
CAS No.	1919045-04-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18,21-heptaoxatetracosan-24-oic acid; m-PEG3-Sulfone-PEG3-acid; PEG-based sulfone-PEG-acid linker; Heterobifunctional PEG sulfone acid; 3,6,9,12,15,18,21-Heptaoxatetracosanoic acid, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-; Maleimide-PEG3-Sulfone-PEG3-COOH
EINECS	Contact for details

Quality Control

Our m-Peg3-Sulfone-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.