Description

Tamra-Peg4-Acid CAS NO 1909223-02-4 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a tetramethylrhodamine (TAMRA) fluorophore and a terminal carboxylic acid group. This bifunctional compound is essential for researchers and manufacturers requiring precise, fluorescent labeling and bioconjugation in aqueous and biological systems. It is primarily utilized in the life sciences and pharmaceutical industries for developing diagnostic assays, targeted drug delivery systems, and advanced bioconjugates.

Application

• Fluorescent Probe Synthesis: Acts as a critical building block for creating fluorescent probes and sensors used in bioimaging and cellular analysis.
• Bioconjugation & Linker Chemistry: The terminal carboxylic acid enables covalent attachment to amines on proteins, peptides, antibodies, and nanoparticles via standard coupling reagents.
• Diagnostic Assay Development: Used to label antibodies, antigens, or oligonucleotides in lateral flow assays, ELISA, and other in vitro diagnostic (IVD) platforms.
• Drug Delivery System Research: Serves as a fluorescent-PEG spacer in the design and tracking of polymer-drug conjugates and liposomal formulations.
• Material Science & Surface Modification: Facilitates the fluorescent functionalization of surfaces, hydrogels, and other biomaterials for study and application.
• Flow Cytometry & Microscopy Standards: Employed in the preparation of calibration standards and fluorescent markers for analytical instruments.

Basic Information

Item	Details
Product Name	Tamra-Peg4-Acid
CAS No.	1909223-02-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5-TAMRA-PEG4-acid; Tetramethylrhodamine-PEG4-COOH; 6-Carboxy-X-rhodamine-PEG4-acid; TAMRA tetraethylene glycol carboxylic acid; TAMRA-PEG4-CH2CH2COOH; Rhodamine-based PEG linker; 5(6)-TAMRA, SE precursor; Fluorescent PEG acid
EINECS	Contact for details

Quality Control

Every batch of Tamra-Peg4-Acid is manufactured and tested under strict quality management systems to ensure high purity and batch-to-batch consistency, critical for reproducible research and development. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store the product in a freezer at -20°C or below under desiccant for long-term stability. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Red to purple solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Single Isomer Content (HPLC)	≥ 90% (5- or 6-isomer)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, MeCN; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.