Description

Biotin-Peg7-Mal CAS NO 1898221-65-2 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a biotin group for affinity capture and a maleimide (Mal) group for site-specific conjugation to thiols. This compound is essential for creating stable, well-defined bioconjugates with minimal impact on the biological activity of the target molecule. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay production, and advanced materials science for applications such as antibody-drug conjugate (ADC) construction, protein labeling, and surface functionalization.

Application

• Site-specific bioconjugation of peptides, proteins, and antibodies via thiol-maleimide chemistry.
• Construction of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Functionalization of nanoparticles, surfaces, and biosensors with biotin for subsequent streptavidin/avidin binding.
• Development of diagnostic assays and imaging probes requiring stable, oriented immobilization.
• Affinity purification and pull-down assays utilizing the high-affinity biotin-streptavidin interaction.
• Crosslinking in hydrogel formation and biomaterial engineering for controlled drug release systems.
• Labeling of oligonucleotides and other biomolecules for detection and tracking.

Basic Information

Product Name	Biotin-Peg7-Mal
CAS No.	1898221-65-2
Molecular Formula	C38H67N5O13S
Molecular Weight	834.0 g/mol
Synonyms	Biotin-PEG7-Maleimide; Biotin-PEG7-Mal; Maleimide-PEG7-Biotin; Mal-PEG7-Biotin; Biotin-PEG7-NHS Ester (precursor); 2-[2-[2-[2-[2-[2-[2-[3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-1-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate; Biotinylated PEG crosslinker
EINECS	Contact for details

Quality Control

Our Biotin-Peg7-Mal is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and functional group integrity are provided with every shipment to support your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Integrity (NMR)	Maleimide & Biotin groups present
Solubility	Soluble in DMSO, DMF, acetonitrile, moderately soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.