Description

Dbco-Peg1 CAS NO 1839049-33-0 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group and a terminal hydroxyl group. This compound is a critical reagent in bioorthogonal chemistry, enabling efficient, catalyst-free conjugation to azide-modified biomolecules under physiological conditions. It is essential for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, where precise and stable cross-linking is required.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of antibodies, proteins, peptides, and small molecule drugs for creating antibody-drug conjugates (ADCs) and other therapeutic constructs.
• PEGylation Reagent: Introducing a short, hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic properties of therapeutic molecules.
• Click Chemistry Labeling: Fluorescent or functional labeling of azide-tagged biomolecules, cells, or materials for imaging, diagnostics, and biosensing applications.
• Surface Functionalization: Modification of nanoparticles, polymers, and solid supports with bio-recognition elements for assay development and targeted delivery systems.
• Cross-linking Agent: Creating stable hydrogels, polymer networks, and biomaterial scaffolds for tissue engineering and 3D cell culture.
• Chemical Biology Probes: Synthesis of activity-based probes and affinity tags for studying protein function and interactions in live cells.

Basic Information

Product Name	Dbco-Peg1
CAS No.	1839049-33-0
Molecular Formula	C19H17NO3
Molecular Weight	307.34 g/mol
Synonyms	DBCO-PEG1-OH; DBCO-PEG1-Alcohol; 1-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-2-hydroxy-3,6,9-trioxaundecan-11-one; Dibenzocyclooctyne-PEG1-Alcohol; DBCO-(CH2CH2O)-CH2CH2OH; Azadibenzocyclooctyne-PEG1-OH; ADIBO-PEG1-OH
EINECS	Contact for details

Quality Control

Our Dbco-Peg1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. For long-term storage, desiccate the container. Allow the product to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.