Description

Pomalidomide-C6-Peg1-C3-Peg1-Butyl Iodide is a high-purity, synthetic chemical intermediate designed for advanced pharmaceutical research and development. This compound is critical for the synthesis of novel, targeted drug conjugates, particularly in the field of oncology and immunomodulation. It is primarily utilized by research institutions, biotechnology firms, and pharmaceutical companies engaged in the development of next-generation therapeutics, including Antibody-Drug Conjugates (ADCs) and targeted small molecules.

Application

• Key Intermediate for ADC (Antibody-Drug Conjugate) Payloads: Serves as a crucial building block for constructing potent cytotoxin-linker systems in ADC development.
• PROTAC (Proteolysis Targeting Chimera) Synthesis: Used in the creation of heterobifunctional molecules designed to degrade specific disease-causing proteins.
• Pharmaceutical Research & Development: Enables the synthesis of novel pomalidomide derivatives and analogs for structure-activity relationship (SAR) studies.
• Bioconjugation Chemistry: The reactive iodide and PEG spacers make it suitable for conjugation to antibodies, proteins, or other targeting moieties.
• Pre-clinical Drug Candidate Synthesis: Employed in the production of candidate molecules for in vitro and in vivo efficacy and toxicity testing.
• Chemical Biology Tool Development: Acts as a functional probe for studying cereblon (CRBN)-mediated protein degradation pathways.

Basic Information

Product Name	Pomalidomide-C6-Peg1-C3-Peg1-Butyl Iodide
CAS No.	1835705-76-4
Molecular Formula	C30H43IN4O8
Molecular Weight	714.59 g/mol
Synonyms	4-((2-(2-(4-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)butoxy)ethoxy)ethyl)amino)-4-oxobutyl Iodide; Pomalidomide-PEG1-C3-PEG1-C4-I; Pomalidomide-C6-PEG1-C3-PEG1-C4-I; Pomalidomide PEGylated Alkyl Iodide Derivative; IMiD-PEG Linker-Iodide Conjugate; CRBN Ligand-PEG-Iodide; (S)-3-(4-((4-((2-(2-(4-Iodobutoxy)ethoxy)ethyl)amino)-4-oxobutoxy)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
EINECS	Contact for details

Quality Control

Our Pomalidomide-C6-Peg1-C3-Peg1-Butyl Iodide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the material should be handled in a dry environment and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.