Description

Pomalidomide-C6-Peg3-Butyl Iodide is a high-purity, synthetic chemical intermediate designed for advanced pharmaceutical research and development. This compound is critical for the synthesis of novel PROTACs (Proteolysis Targeting Chimeras) and other bifunctional molecules, enabling targeted protein degradation. It is primarily utilized by pharmaceutical companies, biotechnology research institutions, and CROs (Contract Research Organizations) engaged in cutting-edge oncology and immunology drug discovery programs.

Application

• PROTAC Linker Synthesis: Serves as a key building block for constructing the linker component in PROTAC molecules, connecting the E3 ligase ligand to the target protein ligand.
• Anticancer Drug Development: Used in the research and preclinical development of next-generation targeted cancer therapies, particularly those leveraging immunomodulatory and protein degradation pathways.
• Bifunctional Molecule Assembly: Essential for creating bifunctional degraders and molecular glues that require a pomalidomide-based E3 ligase recruiting moiety.
• Chemical Biology Research: Employed as a tool compound in chemical biology to study cereblon (CRBN)-mediated protein degradation mechanisms.
• ADC (Antibody-Drug Conjugate) Payload Exploration: Investigated for use in the development of novel ADC payloads with unique mechanisms of action.
• High-Value Intermediate Production: Manufactured as a critical intermediate for custom synthesis services catering to the pharmaceutical industry.

Basic Information

Product Name	Pomalidomide-C6-Peg3-Butyl Iodide
CAS No.	1835705-70-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Pomalidomide-PEG3-C6-I; Pomalidomide-C6-PEG3-Iodide; Pomalidomide PEGylated Alkyl Iodide; 4-((2-(2-(3-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propanamido)ethoxy)ethoxy)ethyl)amino)butyl iodide; PROTAC Linker for Pomalidomide; CRBN Ligand Linker Conjugate; E3 Ligase Recruiter Linker
EINECS	Contact for details

Quality Control

Every batch of Pomalidomide-C6-Peg3-Butyl Iodide is produced and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards and customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.