Description

n-Succinimidyl-6-(2-Pyridyldithio)Capronate is a heterobifunctional crosslinking reagent featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive pyridyldithiol group. This compound matters for its critical role in creating stable, cleavable conjugates between proteins, peptides, and other biomolecules, enabling advanced research and therapeutic development. It is primarily needed by professionals in bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay manufacturing.

Application

• Conjugation of antibodies, proteins, or peptides to enzymes, fluorophores, or drug molecules.
• Critical reagent in the synthesis of antibody-drug conjugates (ADCs) for targeted cancer therapy.
• Immobilization of biomolecules onto solid supports (e.g., sensor chips, beads, plates) for diagnostic assays.
• Site-specific labeling of cysteine-containing proteins for structural and functional studies.
• Preparation of cleavable protein-protein or protein-small molecule complexes for biochemical research.
• Tool compound in proteomics for crosslinking and identifying protein-protein interactions.

Basic Information

Product Name	n-Succinimidyl-6-(2-Pyridyldithio)Capronate
CAS No.	1824718-79-7
Molecular Formula	C18H21N3O6S2
Molecular Weight	439.51 g/mol
Synonyms	SPDP Long Chain; 6-(2-Pyridyldithio)hexanoic Acid N-Hydroxysuccinimide Ester; LC-SPDP; N-Succinimidyl 6-(2-Pyridyldithio)hexanoate; N-Succinimidyl 6-(Pyridin-2-yldisulfanyl)hexanoate; 2,5-Dioxopyrrolidin-1-yl 6-(pyridin-2-yldisulfanyl)hexanoate; NHS-PDP; Long-chain SPDP crosslinker
EINECS	Contact for details

Quality Control

Our n-Succinimidyl-6-(2-Pyridyldithio)Capronate is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for sensitive bioconjugation applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF, acetonitrile
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.