Description

Dota-Nhs-Ester Hexafluorophosphate Tfa Salt (Technical Grade) is a specialized chemical reagent designed for high-performance conjugation and labeling applications. This compound is valued for its role as an activated ester, facilitating efficient and stable amide bond formation under mild conditions. It is primarily utilized by researchers and process chemists in the pharmaceutical, biotechnology, and diagnostics industries for the synthesis of peptide conjugates, antibody-drug conjugates (ADCs), and other biomolecular probes.

Application

• Bioconjugation Reagent: For the covalent attachment of peptides, proteins, or other biomolecules to carriers, labels, or solid supports.
• Antibody-Drug Conjugate (ADC) Synthesis: As a key linker-payload intermediate in the development of targeted cancer therapies.
• Diagnostic Probe Development: In the preparation of fluorescent, radioactive, or enzymatic labels for immunoassays and imaging.
• Peptide Modification: For the site-specific introduction of functional groups, tags, or stabilizing elements into peptide sequences.
• Material Science Functionalization: To modify surfaces of nanoparticles or polymers with bioactive ligands for targeted delivery systems.
• Research & Development: As a critical tool in chemical biology and medicinal chemistry for exploring new therapeutic modalities.

Basic Information

Product Name	Dota-Nhs-Ester Hexafluorophosphate Tfa Salt (Technical Grade)
CAS No.	1823122-52-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	DOTA-NHS ester hexafluorophosphate TFA salt; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid N-hydroxysuccinimide ester hexafluorophosphate TFA salt; DOTA-NHS ester HPF6 TFA salt; DOTA active ester; DOTA tris(t-butyl) ester NHS ester HPF6 TFA salt; Macrocyclic chelator NHS ester; DOTA-tris(tBu)-NHS ester hexafluorophosphate TFA salt
EINECS	Contact for details

Quality Control

Our Technical Grade Dota-Nhs-Ester Hexafluorophosphate Tfa Salt is produced under a quality management system to ensure batch-to-batch consistency for industrial and research applications. While not intended for direct human use, it is manufactured with rigorous purity controls to meet the demanding requirements of chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and relevant impurities is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 90% (Technical Grade)
Water Content (KF)	≤ 2.0 %
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.