Description

Hydroxy-Peg2-Pfp Ester is a specialized bifunctional linker molecule featuring a terminal hydroxyl group and a pentafluorophenyl (Pfp) ester. This compound is engineered to facilitate efficient and selective bioconjugation and PEGylation strategies in advanced chemical synthesis. It is a critical reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-purity building blocks for developing novel therapeutics, diagnostics, and drug delivery systems.

Application

• Bioconjugation Reagent: Used for the covalent attachment of peptides, proteins, or other biomolecules to surfaces, polymers, or other functional molecules via the reactive Pfp ester group.
• PEGylation Linker: Serves as a key intermediate in the synthesis of polyethylene glycol (PEG) derivatives, enabling the introduction of functional handles for further modification.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the construction of linker-payload complexes in ADC manufacturing, leveraging its orthogonal reactivity.
• Polymer Functionalization: Employed to introduce hydroxyl or further reactive sites into polymer backbones for creating smart materials and hydrogels.
• Proteomics Research: Utilized in chemical proteomics for labeling and enriching target proteins or enzymes.
• Diagnostic Probe Synthesis: Acts as a building block for synthesizing fluorescent or radioactive probes used in imaging and diagnostic assays.
• Solid-Phase Peptide Synthesis (SPPS): Can be used as a protected or activatable handle for the stepwise assembly of complex peptides.
• Cross-linking Agent: Enables the formation of stable cross-links between molecules bearing amine groups in material science and biochemistry.

Basic Information

Item	Details
Product Name	Hydroxy-Peg2-Pfp Ester
CAS No.	1820673-42-4
Molecular Formula	C₁₆H₁₆F₅NO₆
Molecular Weight	413.30 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-(2-{2-[2-hydroxyethoxy]ethoxy}ethoxy)benzoic acid pentafluorophenyl ester; HO-PEG2-PFP ester; 4-(2-{2-[2-Hydroxyethoxy]ethoxy}ethoxy)-2,3,5,6-tetrafluorobenzoic acid pentafluorophenyl ester; Pentafluorophenyl 4-(2-{2-[2-hydroxyethoxy]ethoxy}ethoxy)-2,3,5,6-tetrafluorobenzoate; Hydroxy-PEG2-PFP; PFP-PEG2-OH; Pentafluorophenyl ester of HO-PEG2-acid
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg2-Pfp Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.