Description

Mal-Peg8-Acid CAS NO 1818294-46-0 is a heterobifunctional polyethylene glycol (PEG) linker featuring a maleimide group at one terminus and a carboxylic acid at the other, separated by an 8-unit PEG spacer. This compound is critical for creating stable, site-specific bioconjugates, enabling the precise attachment of biomolecules like peptides, proteins, and antibodies to various surfaces, payloads, or other functional molecules. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic drugs to monoclonal antibodies via thiol-maleimide chemistry for targeted cancer therapies.
• PEGylation of Proteins/Peptides: Introduction of a hydrophilic PEG spacer to improve solubility, stability, and circulation half-life of therapeutic biologics.
• Diagnostic Probe Conjugation: Linking fluorescent dyes, enzymes, or other reporter molecules to antibodies or oligonucleotides for immunoassays and biosensors.
• Surface Functionalization: Immobilization of biomolecules onto nanoparticles, microarrays, or biosensor chips through the carboxylic acid group.
• Cross-linking Agent: For creating hydrogels or cross-linked protein matrices in tissue engineering and biomaterial science.
• Small Molecule Prodrug Synthesis: Facilitating the creation of cleavable linkages for controlled drug release applications.

Basic Information

Product Name	Mal-Peg8-Acid
CAS No.	1818294-46-0
Molecular Formula	C33H57NO15
Molecular Weight	707.8 g/mol
Synonyms	Maleimide-PEG8-acid; Maleimide-PEG8-COOH; 3-({2-[2-(2-{2-[2-(2-{2-[2-(2-{3-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methoxy]propoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy)propanoic Acid; 1-[3-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-Methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy)propyl]-1H-pyrrole-2,5-dione-3-carboxylic Acid; Mal-PEG8-COOH; mPEG8-MAL-COOH; 8-Arm PEG Maleimide Acid.
EINECS	Contact for details

Quality Control

Our Mal-Peg8-Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or oil
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Maleimide Functionalization	≥ 90%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, Acetonitrile, Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.