Description

Amino-Peg9-T-Butyl Ester is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive primary amine group and a protected carboxylic acid terminus. This compound is engineered to serve as a critical linker and spacer molecule in advanced bioconjugation and materials science applications, enabling the controlled attachment of biomolecules, drugs, or other functional groups. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require precise, water-soluble linkers for developing novel therapeutics, targeted drug delivery systems, and sophisticated biomaterials.

Application

• Bioconjugation Linker: For coupling peptides, proteins, antibodies, or oligonucleotides to surfaces, nanoparticles, or other molecules via its amine-reactive end.
• Drug Delivery Systems: As a key component in the synthesis of PEGylated prodrugs and antibody-drug conjugates (ADCs) to enhance solubility, stability, and pharmacokinetics.
• Surface Functionalization: To introduce amine groups onto materials, polymers, or nanoparticles for subsequent chemical modification and bio-interface engineering.
• Cross-linking Agent: In the preparation of hydrogels, polymer networks, and biomaterial scaffolds where controlled cross-linking density is required.
• Diagnostic Reagents: For labeling and modifying probes, sensors, and assay components to improve performance and reduce non-specific binding.
• Intermediate Synthesis: As a versatile building block for the custom synthesis of more complex heterobifunctional or multi-arm PEG derivatives.

Basic Information

Product Name	Amino-Peg9-T-Butyl Ester
CAS No.	1818294-44-8
Molecular Formula	C31H63NO12
Molecular Weight	641.8 g/mol
Synonyms	NH2-PEG9-COOtBu; Amino-PEG9-t-butyl ester; α-Amino-ω-(t-butoxycarbonyl)-nonakis(oxyethylene); 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-oic acid, 27-amino-, 1,1-dimethylethyl ester; tert-Butyl 27-amino-3,6,9,12,15,18,21,24,27-nonaoxaheptacosan-1-oate; Amine-PEG9-acid t-butyl ester; Boc-NH-PEG9-acid (Note: This is a common misnomer, the protecting group is t-butyl, not Boc); Amino-PEG9-tBu Ester
EINECS	Contact for details

Quality Control

Every batch of Amino-Peg9-T-Butyl Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, functional group content, and impurity profiles. Our quality commitment aligns with the standards required for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (Functional Amine)	≥ 90.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.