Description

Spdp-Peg6-T-Butyl Ester is a heterobifunctional, amine- and thiol-reactive crosslinking reagent featuring a long, hydrophilic polyethylene glycol (PEG) spacer. This compound is engineered to facilitate the stable conjugation of biomolecules, such as antibodies and proteins, while significantly reducing aggregation and improving solubility. It is an essential tool for researchers and manufacturers in the fields of bioconjugation, diagnostic assay development, and advanced drug delivery systems, where precise and stable linker chemistry is required.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a critical component in the construction of ADCs, connecting cytotoxic payloads to monoclonal antibodies via cleavable or non-cleavable bonds.
• Protein/Peptide Labeling: Used for site-specific modification of proteins and peptides with fluorophores, enzymes, or other reporter molecules for imaging and detection.
• Surface Functionalization: Enables the covalent attachment of biomolecules to nanoparticles, biosensors, and other solid supports for diagnostic and research applications.
• Polymer-Protein Conjugation: Facilitates PEGylation strategies to enhance the pharmacokinetic properties, stability, and solubility of therapeutic proteins.
• Immobilization Chemistry: Employed in the preparation of affinity chromatography resins and microarray surfaces by coupling ligands to activated matrices.
• Crosslinking for Structural Studies: Useful in studying protein-protein interactions and complex structures through the introduction of defined crosslinks.

Basic Information

Product Name	Spdp-Peg6-T-Butyl Ester
CAS No.	1818294-34-6
Molecular Formula	C33H60N2O13S2
Molecular Weight	756.96 g/mol
Synonyms	SPDP-PEG6-t-butyl ester; N-Succinimidyl 3-((2-(2-(3-(t-Butoxy)-3-oxopropoxy)ethoxy)ethoxy)ethyl)carbamoyl)propyl Disulfide; Succinimidyl-[(N-maleimidopropionamido)-hexaethyleneglycol] ester; SMPEG6; Maleimide-PEG6-NHS Ester (related); Heterobifunctional PEG Crosslinker, NHS-PEG6-MAL; 3-((2-(2-(3-(tert-Butoxy)-3-oxopropoxy)ethoxy)ethoxy)ethyl)(2,5-dioxopyrrolidin-1-yl) Carbonyl]propyl] Disulfanyl]propanoic Acid
EINECS	Contact for details

Quality Control

Every batch of Spdp-Peg6-T-Butyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards suitable for research and biopharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and functional integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.