Description

n-Tos-n-(T-Butoxycarbonyl)-Aminoxy-Peg4-Tos CAS NO 1817735-42-4 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring orthogonal protecting groups. This compound is engineered to provide controlled, sequential bioconjugation, which is critical for creating complex molecular architectures with high precision. It is an essential building block for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science, where reliable and specific cross-linking is required.

Application

• Bioconjugation and ADC Development: Used as a key linker for attaching cytotoxic drugs to antibodies in Antibody-Drug Conjugate (ADC) synthesis.
• Peptide and Protein Modification: Enables site-specific PEGylation to enhance the stability, solubility, and pharmacokinetic properties of therapeutic peptides and proteins.
• Cross-linking Reagent: Facilitates the controlled coupling of biomolecules, nanoparticles, or surfaces due to its orthogonal tosyl (Tos) and Boc-protected aminoxy reactive groups.
• Polymer Chemistry: Serves as a functional initiator or monomer for synthesizing tailored PEG-based copolymers with specific end-group functionality.
• Diagnostic Probe Synthesis: Utilized in constructing imaging agents and diagnostic probes by linking targeting moieties to reporter molecules.
• Material Surface Functionalization: Applied to modify surfaces with bioactive molecules for applications in biosensors and tissue engineering scaffolds.

Basic Information

Item	Detail
Product Name	n-Tos-n-(T-Butoxycarbonyl)-Aminoxy-Peg4-Tos
CAS No.	1817735-42-4
Molecular Formula	C31H52N2O13S2
Molecular Weight	724.88 g/mol
Synonyms	Boc-NH-O-PEG4-OTs; 1,11-Bis(tosyl)-3,6,9-trioxa-1,11-diazadodecane-2,10-dione tert-butyl ester; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-[[(1,1-dimethylethoxy)carbonyl]amino]-14-oxo-, 1-(4-methylbenzenesulfonate); Heterobifunctional PEG4 linker, Tosyl-PEG4-Boc-NH-O; Boc-aminoxy-PEG4-tosylate; (Boc-NH-O)-(CH2CH2O)4-Ts
EINECS	Contact for details

Quality Control

Our production of n-Tos-n-(T-Butoxycarbonyl)-Aminoxy-Peg4-Tos adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive); containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Long-term storage is recommended at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.