Description

T-Boc-Aminoxy-Peg4-Tos CAS NO 1807539-01-0 is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (T-Boc) protected aminoxy group and a tosylate (Tos) leaving group. This compound is engineered for the controlled, site-specific conjugation of biomolecules, offering a valuable tool for creating stable oxime linkages. It is primarily utilized by researchers and process developers in the pharmaceutical and biotechnology sectors. Its design facilitates the development of advanced drug delivery systems, bioconjugates, and diagnostic reagents.

Application

• Bioconjugation Reagent: For the site-specific coupling of peptides, proteins, antibodies, or oligonucleotides via oxime bond formation.
• ADC (Antibody-Drug Conjugate) Linker: Serves as a functionalized PEG spacer to connect cytotoxic payloads to monoclonal antibodies, enhancing solubility and pharmacokinetics.
• PEGylation Agent: Used to modify therapeutic proteins and peptides to improve stability, reduce immunogenicity, and prolong circulation half-life.
• Diagnostic Probe Synthesis: Enables the attachment of fluorescent dyes, radiolabels, or other reporter molecules to targeting molecules for imaging applications.
• Polymer Chemistry: Acts as a functional initiator or monomer in the synthesis of tailored, functionalized polymers for biomedical materials.
• Crosslinking Reagent: For creating hydrogels or crosslinked protein matrices with controlled density and functionality.
• Solid-Phase Peptide Synthesis (SPPS): Used as a building block to introduce PEG spacers and orthogonal reactive handles into synthetic peptides.
• Small Molecule Prodrug Development: Facilitates the creation of cleavable linkages between drugs and targeting ligands.

Basic Information

Item	Details
Product Name	T-Boc-Aminoxy-Peg4-Tos
CAS No.	1807539-01-0
Molecular Formula	C27H45NO11S
Molecular Weight	567.72 g/mol
Synonyms	1-Boc-2-aminooxy-3,6,9,12-tetraoxapentadec-14-yl 4-methylbenzenesulfonate; tert-Butyl N-(17-((4-methylphenyl)sulfonyloxy)-3,6,9,12-tetraoxa-16-azaheptadecyloxy)carbamate; T-Boc-NH-O-PEG4-OTs; Boc-Aminoxy-PEG4-Tosylate; BOC-NH-O-PEG4-OTs; Aminoxy-PEG4-Tos BOC Protected; 2-{2-[2-(2-{2-[(tert-Butoxycarbonyl)amino]oxyethoxy}ethoxy)ethoxy]ethoxy}ethyl 4-methylbenzenesulfonate
EINECS	Contact for details

Quality Control

Our T-Boc-Aminoxy-Peg4-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure high batch-to-batch consistency and compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.