Description

Azd-Peg2 -Pfp is a specialized bifunctional PEG-based linker featuring a pentafluorophenyl (Pfp) ester group. This compound is a critical intermediate for the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates, enabling efficient and site-specific coupling of payloads. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of targeted therapeutics and advanced drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key building block for constructing cleavable or non-cleavable linkers connecting cytotoxic drugs to monoclonal antibodies.
• Peptide and Protein Modification: Used for the site-specific PEGylation of peptides, proteins, and enzymes to improve pharmacokinetic properties such as solubility and circulation half-life.
• Prodrug Synthesis: Employed in the design and synthesis of prodrugs where controlled release of the active pharmaceutical ingredient is required.
• Biomolecule Labeling: Facilitates the attachment of fluorescent dyes, affinity tags, or other reporter molecules to biomolecules for diagnostic and research applications.
• Polymer-Assisted Drug Delivery: Acts as a functional monomer or cross-linker in the development of smart polymeric nanoparticles and micelles for targeted drug delivery.
• Solid-Phase Peptide Synthesis (SPPS): Can be used as a reactive handle for the on-resin conjugation of peptides to various cargo molecules.

Basic Information

Product Name	Azd-Peg2 -Pfp
CAS No.	1807537-41-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2,3,5,6-Tetrafluoro-4-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)phenyl benzoate; Pentafluorophenyl-PEG2-azide; Azido-PEG2-PFP ester; Azido-PEG2-PFP; PFP-PEG2-N3; 4-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethoxy)-2,3,5,6-tetrafluorophenyl benzoate
EINECS	Contact for details

Quality Control

Our Azd-Peg2 -Pfp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.