Description

Hydroxy-Peg3-Pfp Ester is a specialized heterobifunctional polyethylene glycol (PEG) linker featuring a reactive pentafluorophenyl (PFP) ester and a terminal hydroxyl group. This compound is a critical reagent in bioconjugation and pharmaceutical development, enabling the efficient and selective coupling of biomolecules under mild conditions. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, antibody-drug conjugate (ADC) development, and peptide synthesis.

Application

• Bioconjugation Linker: For coupling peptides, proteins, or antibodies to other molecules, surfaces, or drug payloads.
• Antibody-Drug Conjugate (ADC) Synthesis: As a key component in constructing stable, cleavable, or non-cleavable linkers for targeted cancer therapies.
• PEGylation Reagent: To introduce polyethylene glycol chains onto drugs or biomolecules to improve solubility, stability, and pharmacokinetic profiles.
• Proteomics Research: For labeling and cross-linking applications in protein interaction studies and mass spectrometry.
• Polymer Chemistry: As a building block for synthesizing functionalized PEG-based polymers and hydrogels.
• Diagnostic Reagent Development: In the creation of fluorescent or detection probes for immunoassays and biosensors.

Basic Information

Product Name	Hydroxy-Peg3-Pfp Ester
CAS No.	1807537-40-1
Molecular Formula	C17H19F5O6
Molecular Weight	438.33 g/mol
Synonyms	HO-PEG3-PFP Ester; 4,7,10-Trioxa-1,13-tridecanedioic acid, 13-[(2,3,4,5,6-pentafluorophenoxy)carbonyl]-, 1-hydroxytridecyl ester; Pentafluorophenyl ester of triethylene glycol monoacetic acid; PFP-PEG3-OH; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-oxo-14-(pentafluorophenoxy)-, 1-hydroxytetradecyl ester; 3,6,9-Trioxaundecanedioic acid, 11-[(pentafluorophenoxy)carbonyl]-, 1-hydroxyundecyl ester; PFP-PEG3-OH; Hydroxy-PEG3-PFP
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg3-Pfp Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications from HPLC, NMR, and MS are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent hydrolysis of the active ester.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.