Description

Tos-Peg3-Ch2Co2H CAS NO 1807537-35-4 is a heterobifunctional polyethylene glycol (PEG) linker featuring a tosylate (Tos) leaving group and a carboxylic acid (CO2H) terminus, separated by a triethylene glycol spacer. This molecular architecture is critical for creating stable, hydrophilic conjugates in bioconjugation and pharmaceutical development. It is an essential building block for researchers and manufacturers in the life sciences sector who require precise, reliable, and soluble cross-linking agents.

Application

• Bioconjugation Reagent: Used for coupling biomolecules (e.g., peptides, proteins, antibodies) to other entities like drugs, dyes, or solid surfaces via its reactive tosylate and carboxylate groups.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker component to attach cytotoxic payloads to monoclonal antibodies, leveraging the PEG spacer to improve solubility and pharmacokinetics.
• PEGylation Chemistry: Acts as a functionalized PEG derivative for modifying therapeutic proteins and nanoparticles to enhance stability, reduce immunogenicity, and prolong circulation half-life.
• Polymer and Material Science: Employed as a monomer or cross-linker in the synthesis of functionalized hydrogels, smart polymers, and biocompatible coatings.
• Diagnostic Probe Synthesis: Facilitates the construction of imaging agents and diagnostic probes by linking targeting moieties to reporter molecules.
• Small Molecule Prodrug Synthesis: Enables the design of prodrugs with improved aqueous solubility and controlled release profiles through its cleavable linker properties.

Basic Information

Product Name	Tos-Peg3-Ch2Co2H
CAS No.	1807537-35-4
Molecular Formula	C18H28O9S
Molecular Weight	444.48 g/mol
Synonyms	2-[2-[2-(2-Tosyloxyethoxy)ethoxy]ethoxy]acetic Acid; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-(4-methylbenzenesulfonate); Tos-PEG3-acid; PEG3 Tosylate Acetic Acid; 13-[(4-Methylphenyl)sulfonyl]-2,5,8,11-tetraoxatetradecan-14-oic Acid; Heterobifunctional PEG Linker Tos-PEG3-COOH; p-Toluenesulfonate PEG3 propionic acid (isomer); Tosyl-PEG3-acid
EINECS	Contact for details

Quality Control

Our Tos-Peg3-Ch2Co2H is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.