Description

Mal-Peg1-Pfp is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and a pentafluorophenyl (Pfp) ester. This compound is engineered for the site-specific conjugation of thiol-containing molecules (via the maleimide) to amine-containing molecules (via the active ester), offering high efficiency and selectivity. It is a critical reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, enabling the creation of stable protein-drug conjugates, functionalized surfaces, and novel polymeric biomaterials.

Application

• Bioconjugation and ADC Development: Site-specific coupling of antibodies, peptides, or proteins with cytotoxic drugs, fluorophores, or other payloads for therapeutic and diagnostic applications.
• PEGylation Chemistry: Introduction of a short, hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic properties of bioactive molecules.
• Surface Functionalization: Modification of nanoparticles, biosensors, or chromatographic media with bioactive ligands for targeted delivery or specific capture.
• Hydrogel and Biomaterial Synthesis: Crosslinking agent for creating PEG-based hydrogels with tailored mechanical properties and biofunctionalization sites for tissue engineering.
• Protein Immobilization: Covalent attachment of enzymes or other proteins to solid supports for biocatalysis or assay development.
• Polymer Chemistry: Building block for synthesizing functional, linear, or branched copolymers with reactive handles for further modification.

Basic Information

Product Name	Mal-Peg1-Pfp
CAS No.	1807530-08-0
Molecular Formula	C19H18F5NO6
Molecular Weight	475.35 g/mol
Synonyms	Maleimide-PEG1-PFP ester; 3-Maleimidopropionic acid PFP ester; Pentafluorophenyl 3-maleimidopropanoate; 2,5-Dioxopyrrolidin-1-yl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate (PFP ester analog); Mal-PEG1-PFP; Maleimide-PEG1-Pentafluorophenyl ester; 1-[3-(2,3,4,5,6-Pentafluorophenoxy)-3-oxopropyl]-1H-pyrrole-2,5-dione; Heterobifunctional PEG crosslinker (Mal-PFP)
EINECS	Contact for details

Quality Control

Every batch of Mal-Peg1-Pfp is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high lot-to-lot consistency and purity suitable for research and bioconjugation applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.