Description

Propargyl-Peg1-Ss-Peg1-T-Butyl Ester is a specialized bifunctional linker molecule featuring both a propargyl group and a tert-butyl ester, connected via a polyethylene glycol (PEG) spacer and a disulfide (SS) bond. This unique structure makes it a critical reagent in advanced bioconjugation and click chemistry applications, enabling the controlled assembly and release of payloads. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing targeted drug delivery systems, antibody-drug conjugates (ADCs), and diagnostic probes.

Application

• Bioconjugation Reagent: A key building block for linking therapeutic molecules (e.g., cytotoxic drugs, imaging agents) to targeting moieties like antibodies or peptides.
• Controlled Release Systems: The disulfide (SS) bond is cleavable under reducing conditions (e.g., in the intracellular environment), enabling site-specific payload release in drug delivery platforms.
• Click Chemistry: The propargyl group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for efficient and modular biomolecule labeling and functionalization.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of linker-payload constructs for next-generation ADCs, improving stability and therapeutic index.
• Polymer and Material Science: Serves as a functional monomer or cross-linker for creating smart, stimuli-responsive hydrogels and biomaterials.
• Proteomics Research: Facilitates the study of protein interactions and dynamics through reversible covalent labeling strategies.

Basic Information

Product Name	Propargyl-Peg1-Ss-Peg1-T-Butyl Ester
CAS No.	1807518-78-0
Molecular Formula	C15H26O5S2
Molecular Weight	350.49 g/mol
Synonyms	Propargyl-PEG1-SS-PEG1-t-butyl ester; 3-[2-[2-(2-tert-Butoxy-2-oxoethoxy)ethyl]disulfanyl]ethoxy]prop-2-yn-1-yl acetate (alternative representation); t-Butyl 2-[2-[2-(2-propyn-1-yloxy-2-oxoethoxy)ethyl]disulfanyl]ethoxy]acetate; Propargyl-PEG-SS-PEG-tBu ester; Alkyne-PEG1-SS-PEG1-OtBu; Bifunctional PEG linker with alkyne and t-butyl ester; SS-PEG linker; Cleavable PEG crosslinker.
EINECS	Contact for details

Quality Control

Our Propargyl-Peg1-Ss-Peg1-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.