Description

Fmoc-n-Methyl-n-Amido-Peg2-Acid is a specialized, high-purity building block used in solid-phase peptide synthesis (SPPS). This compound matters for its role in introducing a polyethylene glycol (PEG) spacer with a methylated amide linkage, which is crucial for enhancing the solubility, bioavailability, and stability of therapeutic peptides. Pharmaceutical researchers and fine chemical manufacturers need it for the development of peptide-based drugs, bioconjugates, and advanced research compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for incorporating PEGylated, methylated linkers into peptide chains.
• Peptide Drug Development: Used to modify peptide backbones to improve pharmacokinetic properties such as solubility and metabolic stability.
• Bioconjugation: Serves as a linker molecule for attaching peptides to other biomolecules, dyes, or drug delivery systems.
• Research Chemicals: Employed in academic and industrial R&D for exploring novel peptide architectures and functions.
• API Intermediate: Acts as a critical raw material in the synthesis of Active Pharmaceutical Ingredients (APIs) for peptide therapeutics.
• Prodrug Synthesis: Utilized in the design of prodrugs where controlled release or targeted delivery is required.

Basic Information

Product Name	Fmoc-n-Methyl-n-Amido-Peg2-Acid
CAS No.	1807518-77-9
Molecular Formula	C25H30N2O7
Molecular Weight	470.52 g/mol
Synonyms	Fmoc-N-Me-NH-PEG2-acid; 2-{2-[2-(9H-Fluoren-9-ylmethoxycarbonyl-methyl-amino)-ethoxy]-ethoxy}-acetic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-2,2'-ethylenedioxydiacetic Acid; Fmoc-N-methyl-2,2'-(ethylenedioxy)diacetic Acid; Fmoc-N-Me-8-amino-3,6-dioxaoctanoic Acid; Fmoc-N-methyl-PEG2-acid; N-Fmoc-N-methyl-3,6-dioxaoctanedioic acid monoamide
EINECS	Contact for details

Quality Control

Our Fmoc-n-Methyl-n-Amido-Peg2-Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality control protocols are designed to meet the stringent requirements of peptide synthesis and API development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.