Description

Mal-Peg1-Nhs Ester CAS NO 1807518-72-4 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group for thiol conjugation and an NHS ester for amine coupling. This compound is essential for creating stable, site-specific bioconjugates with controlled linker lengths, crucial for maintaining bioactivity. It is primarily used by researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced drug delivery systems where precise protein and antibody modification is required.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies via cysteine residues.
• Protein-Polymer Conjugation: To PEGylate therapeutic proteins and peptides, enhancing solubility, stability, and circulation half-life.
• Surface Functionalization: For immobilizing biomolecules (e.g., peptides, antibodies) onto biosensor chips, nanoparticles, or chromatography resins.
• Diagnostic Reagent Development: In the synthesis of enzyme-antibody or fluorophore-antibody conjugates for ELISA and immunofluorescence assays.
• Hydrogel Formation: As a crosslinking agent for creating biomimetic hydrogels used in 3D cell culture and tissue engineering.
• Nanoparticle Targeting: To attach targeting ligands (e.g., peptides, folates) to the surface of drug-loaded nanoparticles.

Basic Information

Product Name	Mal-Peg1-Nhs Ester
CAS No.	1807518-72-4
Molecular Formula	C17H22N2O8
Molecular Weight	382.37 g/mol
Synonyms	Maleimide-PEG1-NHS ester; 3-Maleimidopropionic acid N-hydroxysuccinimide ester; NHS-PEG1-Maleimide; MAL-PEG1-NHS; N-(3-Maleimidopropionyloxy)succinimide; 2,5-Dioxopyrrolidin-1-yl 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate; 1-[3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyloxy]-2,5-pyrrolidinedione; PEG1 crosslinker
EINECS	Contact for details

Quality Control

Our Mal-Peg1-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.