Description

Bromoacetamido-Peg4-Acid CAS NO 1807518-67-7 is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive bromoacetamide group and a carboxylic acid terminus. This compound is a critical reagent in bioconjugation and pharmaceutical development, enabling the precise, site-specific attachment of biomolecules, drugs, or probes. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, antibody-drug conjugate (ADC) development, and advanced material science.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key building block for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• PEGylation Reagent: Used to modify peptides, proteins, or nanoparticles with a hydrophilic PEG spacer to enhance solubility, stability, and circulation half-life.
• Bioconjugation and Crosslinking: Facilitates the covalent coupling of molecules via the reactive bromoacetamide group (targeting thiols) and the carboxylic acid group (for amide bond formation).
• Surface Functionalization: Employed to modify solid surfaces (e.g., chips, beads) with functional groups for biosensor development or affinity chromatography.
• Prodrug Synthesis: Serves as a spacer in the design of prodrugs, allowing for controlled drug release mechanisms.
• Diagnostic Reagent Preparation: Used in the synthesis of labeled probes and contrast agents for imaging and diagnostic applications.

Basic Information

Product Name	Bromoacetamido-Peg4-Acid
CAS No.	1807518-67-7
Molecular Formula	C15H26BrN2O8
Molecular Weight	439.28 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-[(2-bromoacetyl)amino]-; Bromoacetamido-PEG4-acid; Bromoacetamido tetraethylene glycol carboxylic acid; α-Bromoacetamido-ω-carboxy tetraethylene glycol; BrAc-NH-PEG4-COOH; 15-Bromo-3,6,9,12-tetraoxa-14-azapentadecanoic acid; Bromoacetyl-PEG4-acid; N-(2-(2-(2-(2-Carboxyethoxy)ethoxy)ethoxy)ethyl)-2-bromoacetamide
EINECS	Contact for details

Quality Control

Our Bromoacetamido-Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.