Description

Mal-Peg5-Pfp is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and a pentafluorophenyl (PFP) ester. This compound is engineered for the site-specific conjugation of biomolecules, enabling the creation of stable, well-defined bioconjugates. It is a critical reagent for researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and advanced materials development, where precise and controlled coupling is essential.

Application

• Antibody-Drug Conjugate (ADC) Development: For the controlled attachment of cytotoxic payloads to antibodies via thiol-maleimide chemistry.
• PEGylation of Peptides and Proteins: To modify therapeutic proteins, enhancing their solubility, stability, and pharmacokinetic profiles.
• Surface Functionalization: For immobilizing biomolecules onto sensor chips, nanoparticles, or other solid supports for diagnostic and research applications.
• Crosslinking Agent: Used in the synthesis of hydrogels, polymer networks, and biomaterials with tailored properties.
• Bioconjugate Probe Synthesis: Creating fluorescent, affinity, or other labeled probes for imaging, detection, and pull-down assays.
• Linker for Small Molecule Conjugation: Facilitating the attachment of small molecule drugs or tags to larger carrier molecules.

Basic Information

Product Name	Mal-Peg5-Pfp
CAS No.	1807512-46-4
Molecular Formula	C31H40F5NO11
Molecular Weight	697.65 g/mol
Synonyms	Maleimide-PEG5-PFP ester; Maleimide-PEG5-Pentafluorophenyl ester; 3-Maleimidopropanoic acid, 2,5-dioxo-1-pyrrolidinyl ester, polymer-bound; PFP-PEG5-Maleimide; Pentafluorophenyl-PEG5-Maleimide; Mal-PEG5-OPfp; N-(3-Maleimidopropionyl)-3,6,9,12,15-pentaoxaoctadecan-18-oic acid pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Mal-Peg5-Pfp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, NMR structural confirmation, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.