Description

Dde Biotin-Peg4-Dbco is a multifunctional, high-purity chemical reagent designed for advanced bioconjugation and click chemistry applications. This compound is critical for researchers and developers requiring precise, stable, and bioorthogonal labeling of biomolecules such as proteins, antibodies, and oligonucleotides. It is essential for professionals in pharmaceutical R&D, proteomics, and diagnostic assay development who need reliable, high-quality linkers for constructing complex bioconjugates.

Application

• Bioconjugation and Protein Labeling: Used as a key linker for attaching biotin tags to proteins, antibodies, and other biomolecules via copper-free click chemistry (DBCO-azide cycloaddition).
• Proteomics and Biomarker Discovery: Enables the site-specific modification and enrichment of peptides and proteins for mass spectrometry analysis and pull-down assays.
• Diagnostic Assay Development: Facilitates the construction of sensitive detection platforms, such as ELISA and lateral flow assays, by linking detection molecules to solid supports or signal amplifiers.
• ADC (Antibody-Drug Conjugate) Research: Serves as a versatile building block in the synthesis of next-generation ADCs, allowing for controlled drug-to-antibody ratio (DAR) and stable linker-payload attachment.
• Cell Surface Engineering and Imaging: Allows for the specific labeling of cell surface receptors and glycans for fluorescence imaging and flow cytometry studies.
• Nucleic Acid Modification: Applied in the functionalization of oligonucleotides (DNA/RNA) for targeted delivery, sensing, and diagnostic applications.
• Material Science and Hydrogel Functionalization: Used to incorporate bioactive ligands into polymers, nanoparticles, and hydrogels for tissue engineering and controlled release systems.

Basic Information

Product Name	Dde Biotin-Peg4-Dbco
CAS No.	1807512-43-1
Molecular Formula	C₅₃H₇₆N₈O₁₃S
Molecular Weight	1049.3 g/mol
Synonyms	1-(17-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-4,7,10,13-tetraoxa-16-azaheptadecan-1-oyl)-4-((4-((2-(biotinamido)ethyl)amino)-4-oxobutanoyl)amino)benzyl (1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethyl carbonate; DBCO-PEG4-Biotin Dde; Biotin-PEG4-DBCO Dde; Dde Protected Biotin-PEG4-DBCO; DBCO-PEG4-Biotin with Dde Protection; N-(DBCO-PEG4)-Biotin Dde; Biotin Dde PEG4 DBCO; Click Chemistry Biotin Reagent
EINECS	Contact for details

Quality Control

Our Dde Biotin-Peg4-Dbco is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity (>95%) and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.