Description

Azido-Peg5-Tfp Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a tetrafluorophenyl (Tfp) ester. This compound is engineered for efficient and selective bioconjugation, enabling the stable linkage of biomolecules under mild, aqueous conditions. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced material science, facilitating the creation of antibody-drug conjugates (ADCs), peptide modifications, and functionalized surfaces.

Application

• Bioconjugation and ADC (Antibody-Drug Conjugate) Development: The azide group enables copper-free click chemistry with alkynes, while the Tfp ester reacts efficiently with primary amines, allowing for the stable attachment of cytotoxic drugs to targeting antibodies.
• Peptide and Protein Modification: Used to install PEG chains (PEGylation) onto peptides or proteins to enhance solubility, stability, and circulation half-life.
• Surface Functionalization and Biomaterial Engineering: Facilitates the covalent attachment of bioactive ligands to nanoparticles, hydrogels, or diagnostic arrays to create smart, responsive materials.
• Crosslinking Agent for Polymer Chemistry: Serves as a versatile linker in the synthesis of functionalized polymers and dendrimers with precise architecture.
• Fluorescent Probe and Diagnostic Reagent Synthesis: Acts as a key intermediate for conjugating fluorophores or other reporter molecules to targeting moieties for imaging and detection.
• Chemical Biology Tool Development: Enables the site-specific labeling and study of biomolecular interactions in complex biological systems.

Basic Information

Product Name	Azido-Peg5-Tfp Ester
CAS No.	1807505-31-2
Molecular Formula	C27H38F4N4O9
Molecular Weight	638.61 g/mol
Synonyms	Azido-PEG5-TFP ester; 2,3,5,6-Tetrafluorophenyl 3-azidopropyl(8-{2-[2-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl})carbamate; 3-Azidopropyl(8-{2-[2-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl})carbamic Acid 2,3,5,6-Tetrafluorophenyl Ester; Azido-PEG5-TFP Ester; N-(3-Azidopropyl)-N'-[8-(2-{2-[2-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl)carbamic Acid Tetrafluorophenyl Ester; Heterobifunctional PEG Crosslinker, Azide-TFP; TFP-PEG5-Azide
EINECS	Contact for details

Quality Control

Our Azido-Peg5-Tfp Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your research and cGMP-compliant production needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.