Description

Propargyl-Peg1-Ss-Peg1-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl group and a carboxylic acid, connected by a disulfide bond. This compound is specifically engineered for bioconjugation and click chemistry applications, offering a cleavable linkage for controlled release. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science, enabling the precise construction and modification of biomolecules.

Application

• Bioconjugation and ADC Development: Used to attach cytotoxic drugs to antibodies via cleavable disulfide linkages for Antibody-Drug Conjugates (ADCs).
• Click Chemistry Reagent: The terminal alkyne (propargyl) group enables efficient, site-specific conjugation with azide-functionalized molecules under copper-catalyzed conditions.
• Controlled Release Systems: The disulfide (Ss) bond is selectively cleaved in reducing environments (e.g., intracellular glutathione), facilitating targeted drug release.
• PEGylation and Solubility Enhancement: The PEG spacer improves the solubility and pharmacokinetic properties of conjugated therapeutic peptides and proteins.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and other material surfaces with cleavable, bioactive ligands.
• Crosslinking Agent: Serves as a heterobifunctional crosslinker for coupling amine-containing and alkyne-containing molecules.

Basic Information

Item	Detail
Product Name	Propargyl-Peg1-Ss-Peg1-Acid
CAS No.	1807503-85-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Propargyl-PEG1-SS-PEG1-acid; 3-[2-[2-(2-Prop-2-ynoxyethoxy)disulfanyl-ethoxy]ethoxy]propanoic Acid; Propargyl-PEG1-disulfide-PEG1-COOH; Alkyne-PEG1-SS-PEG1-Acid; Heterobifunctional PEG linker, Propargyl/COOH, cleavable; Propargyl-O-(CH2)2-SS-(CH2)2-O-(CH2)2-COOH
EINECS	Contact for details

Quality Control

Our Propargyl-Peg1-Ss-Peg1-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for research and biopharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The product is moisture-sensitive and should be kept in a dry environment. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.