Description

Desthiobiotin-Peg4-Alkyne is a high-purity, multifunctional chemical building block designed for advanced bioconjugation and click chemistry applications. This compound is critical for researchers and developers requiring precise, stable, and efficient labeling of biomolecules, such as proteins and nucleic acids. It is an essential reagent for professionals in pharmaceutical R&D, proteomics, and diagnostic assay development who need reliable, high-quality linkers for creating targeted biotherapeutics and sophisticated research tools.

Application

• Bioconjugation and Linker Chemistry: Serves as a versatile spacer and linker for attaching biotin analogs or other functional groups to biomolecules, antibodies, or nanoparticles.
• Click Chemistry Reagent: The terminal alkyne group enables efficient, copper-catalyzed azide-alkyne cycloaddition (CuAAC) for site-specific labeling and modification.
• Proteomics and Protein Research: Used for labeling, pull-down assays, and affinity purification of proteins using streptavidin-biotin interaction systems.
• Diagnostic Assay Development: Facilitates the creation of sensitive and specific detection probes for ELISA, lateral flow assays, and other diagnostic platforms.
• ADC (Antibody-Drug Conjugate) Development: Acts as a component in the construction of stable, cleavable linkers for targeted drug delivery systems.
• Chemical Biology Probes: Enables the synthesis of activity-based probes for studying enzyme function and metabolic pathways.
• Materials Science and Surface Functionalization: Used to modify surfaces with biotinylated compounds for biosensor development and microarray technology.

Basic Information

Item	Detail
Product Name	Desthiobiotin-Peg4-Alkyne
CAS No.	1802907-99-8
Molecular Formula	C27H47N3O9S
Molecular Weight	589.75 g/mol
Synonyms	Desthiobiotin-PEG4-Alkyne; 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethoxy)ethyl)pentanamide; N-(17-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-3,6,9,12-tetraoxa-16-azaheptadec-1-yn-1-yl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide; Alkyne-PEG4-Desthiobiotin; Desthiobiotin-PEG4-Alkyne; Propargyl-PEG4-Desthiobiotin
EINECS	Contact for details

Quality Control

Our Desthiobiotin-Peg4-Alkyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.