Description

Pc Alkyne-Peg4-Nhs Carbonate Ester is a heterobifunctional crosslinker featuring an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and an NHS ester for efficient amine coupling. This compound is essential for creating stable, site-specific bioconjugates, particularly in the development of antibody-drug conjugates (ADCs) and other advanced therapeutic modalities. Researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay development rely on its precise reactivity to label and functionalize biomolecules.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via the alkyne handle.
• Protein and Peptide Labeling: Functionalization of amine-containing biomolecules with fluorescent dyes, biotin, or other probes for imaging and detection.
• Surface Modification: Immobilization of biomolecules onto solid supports (e.g., biosensor chips, microarray slides) for assay development.
• Polymer Chemistry: Synthesis of functionalized PEG-based polymers and hydrogels for drug delivery and tissue engineering applications.
• Chemical Biology Probes: Construction of activity-based probes for target identification and validation in drug discovery.
• Diagnostic Reagent Synthesis: Production of key intermediates for immunoassays and molecular diagnostics.

Basic Information

Product Name	Pc Alkyne-Peg4-Nhs Carbonate Ester
CAS No.	1802907-98-7
Molecular Formula	C31H44N2O13
Molecular Weight	652.7 g/mol
Synonyms	Alkyne-PEG4-NHS Carbonate; Propargyl-PEG4-NHS Carbonate; NHS-PEG4-Alkyne; N-(3-Propynyl)-3,6,9,12-tetraoxapentadecan-15-oic acid, 2,5-dioxo-1-pyrrolidinyl ester; 2,5-Dioxopyrrolidin-1-yl 3,6,9,12-tetraoxa-15-azapentadec-14-ynoate; Propargyl-PEG4-NHS ester; Alkyne-PEG4-NHS ester; Bifunctional PEG linker Alkyne-NHS
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. Each batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity, purity, and functional integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request. We adhere to cGMP guidelines for the production of key intermediates intended for preclinical and clinical-stage therapeutic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and the NHS ester moiety is susceptible to hydrolysis. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.