Description

Methyltetrazine-Peg4-Acid CAS NO 1802907-91-0 is a heterobifunctional crosslinking reagent featuring a methyltetrazine group for bioorthogonal click chemistry and a terminal carboxylic acid for facile conjugation to amine-containing molecules. This compound is critical for advanced bioconjugation strategies, enabling the rapid, specific, and catalyst-free labeling of biomolecules in complex biological environments. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, proteomics, and in vivo diagnostics for constructing antibody-drug conjugates (ADCs), imaging probes, and other sophisticated therapeutic and diagnostic platforms.

Application

• Conjugation of antibodies, proteins, and peptides for the development of antibody-drug conjugates (ADCs) and targeted therapeutics.
• Synthesis of bioimaging probes and contrast agents for fluorescence, PET, or SPECT imaging.
• Surface functionalization of nanoparticles, polymers, and solid supports for diagnostic assay development.
• Labeling of oligonucleotides and other biomolecules for cellular tracking and biodistribution studies.
• Construction of chemical biology toolkits for studying protein-protein interactions and post-translational modifications.
• Preparation of affinity chromatography resins and other separation media.
• Development of theragnostic agents that combine therapeutic and diagnostic functions.
• Material science applications for creating functionalized hydrogels and biomaterials.

Basic Information

Product Name	Methyltetrazine-Peg4-Acid
CAS No.	1802907-91-0
Molecular Formula	C24H38N6O9
Molecular Weight	554.60 g/mol
Synonyms	5-Methyl-1,2,4,5-tetrazine-3-carboxylic acid-PEG4-acid; Methyltetrazine-PEG4-COOH; 3-(2,5,8,11-Tetraoxatetradecan-14-yl) 5-methyl-1,2,4,5-tetrazine-3-carboxylate; Methyl-Tetrazine-PEG4-Acid; m-Tetrazine-PEG4-acid; TZ-PEG4-COOH; 5-Methyl-1,2,4,5-tetrazine-3-polyethylene glycol carboxylic acid; Click Chemistry Reagent 1802907-91-0
EINECS	Contact for details

Quality Control

Our Methyltetrazine-Peg4-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange viscous oil or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.