Description

Abz-Amyloid β/A4 Protein Precursor770 (669-674)-Eddnp Trifluoroacetate Salt Abz-Val-Lys-Met-Asp-Ala-Glu-Eddnp Trifluoroacetate Salt is a high-purity, fluorogenic peptide substrate designed for advanced biochemical research. This compound is specifically engineered for the sensitive and selective detection of key proteolytic enzymes, such as β-secretase (BACE1), which are critical targets in neurodegenerative disease studies. It is an essential tool for pharmaceutical R&D, academic research, and diagnostic assay development focused on Alzheimer's disease pathways and other amyloidogenic processes.

Application

• Enzyme Activity Assays: Primary substrate for fluorometric assays measuring β-secretase (BACE1) activity in vitro.
• Drug Discovery & Screening: High-throughput screening (HTS) of potential BACE1 inhibitor compounds for Alzheimer's disease therapeutics.
• Biochemical Research: Kinetic studies and mechanistic analysis of amyloid precursor protein (APP) cleavage and processing.
• Diagnostic Development: Key component in developing clinical and research-grade diagnostic kits for protease activity.
• Neuroscience Studies: Investigation of the molecular pathways involved in amyloid-β peptide production and aggregation.
• Quality Control: Used as a reference standard in QC laboratories for validating assay performance and reagent consistency.

Basic Information

Product Name	Abz-Amyloid β/A4 Protein Precursor770 (669-674)-Eddnp Trifluoroacetate Salt Abz-Val-Lys-Met-Asp-Ala-Glu-Eddnp Trifluoroacetate Salt
CAS No.	1802078-43-8
Molecular Formula	C58H78N14O22S • xC2HF3O2
Molecular Weight	~1419.36 g/mol (Free peptide base)
Synonyms	Abz-VKMDAE-Eddnp TFA Salt; BACE1 Fluorogenic Substrate IV; APP(669-674) Fluorogenic Peptide; β-Secretase Substrate, Fluorogenic; Swedish Mutant APP Substrate; (Abz)SEVNLDAE(Eddnp); Amyloid Precursor Protein 770 Fragment (669-674); AβPP Fluorogenic Substrate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade biochemicals. Each batch is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity, purity, and correct molecular structure. Certificates of Analysis (COA) detailing purity, peptide content, and TFA content are available upon request. We adhere to a quality management system to ensure batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
TFA Content	≤ 15.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.