Description

Mal-Peg4-Va CAS NO 1800456-31-8 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group and a vinyl acetate moiety, separated by a tetraethylene glycol spacer. This compound is essential for creating stable, site-specific conjugations in biopharmaceutical development, particularly for antibody-drug conjugates (ADCs) and protein-polymer hybrids. It is primarily utilized by researchers and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors who require precise and controllable bioconjugation strategies.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to antibodies via cysteine residues.
• Protein-Polymer Conjugation: Functionalization of therapeutic proteins with PEG chains to enhance pharmacokinetic properties.
• Peptide Modification: Introduction of functional handles or labels onto peptides for diagnostic or therapeutic applications.
• Surface Functionalization: Modification of nanoparticles, biosensors, or chromatographic media with bioactive ligands.
• Hydrogel Formation: Crosslinking agent in the synthesis of biocompatible hydrogels for drug delivery or tissue engineering.
• Bioconjugation Tool: A key reagent in research for studying protein interactions, cellular targeting, and drug delivery mechanisms.

Basic Information

Product Name	Mal-Peg4-Va
CAS No.	1800456-31-8
Molecular Formula	C21H33NO10
Molecular Weight	459.5 g/mol
Synonyms	Maleimide-PEG4-Vinyl Acetate; 4-((3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl)oxy)-2,5,8,11-tetraoxatridec-12-en-13-yl acetate; VA-PEG4-MAL; Maleimide-PEG4-VAc; PEG4 Maleimide Vinyl Acetate; 1-(3-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)oxy)-3-oxopropyl)-2,5,8,11-tetraoxatridec-13-en-13-yl acetate; N-(3-Maleimidopropionyl)-PEG4-vinyl acetate
EINECS	Contact for details

Quality Control

Our Mal-Peg4-Va is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.