Description

Biotin-Peg5-Oh CAS NO 1778736-31-4 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin moiety at one terminus and a hydroxyl group at the other. This compound is essential for creating stable, site-specific conjugations in bioconjugation and drug delivery applications, enabling the precise attachment of biomolecules to surfaces, nanoparticles, or other therapeutic agents. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing targeted therapies, biosensors, and advanced research reagents.

Application

• ADC (Antibody-Drug Conjugate) Development: As a key linker component for attaching cytotoxic payloads to monoclonal antibodies via the hydroxyl group, with the biotin end enabling purification or detection.
• Diagnostic Assay & Biosensor Fabrication: For immobilizing proteins, peptides, or nucleic acids onto streptavidin-coated plates, beads, or chips to create sensitive detection platforms.
• Nanoparticle Functionalization: To biotinylate the surface of liposomes, polymeric nanoparticles, or quantum dots for targeted drug delivery and imaging.
• Affinity Chromatography & Pull-Down Assays: Used to synthesize ligands for purifying or isolating biotin-binding proteins and complexes.
• Protein & Peptide Modification: Enables the site-specific PEGylation of biomolecules to improve solubility, stability, and pharmacokinetic profiles.
• Chemical Biology & Proteomics Research: Serves as a versatile tool for studying protein-protein interactions, cellular trafficking, and labeling.

Basic Information

Product Name	Biotin-Peg5-Oh
CAS No.	1778736-31-4
Molecular Formula	C₂₉H₅₄N₄O₁₀S
Molecular Weight	658.8 g/mol
Synonyms	Biotin-PEG5-alcohol; Biotin-PEG5-OH; 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(17-hydroxy-3,6,9,12,15-pentaoxaheptadec-1-yl)pentanamide; Biotinylated PEG5 alcohol; Biotin-Pentaethylene glycol; Biotin-PEG5-OH; PEG5-Biotin; Biotinamidopentyl-PEG5-OH
EINECS	Contact for details

Quality Control

Our Biotin-Peg5-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C to -10°C for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.