Description

2-Cyanoethyl((R)-2,5,7,8-Tetramethyl-2-((4R,8R)-4,8,12-Trimethyltridecyl)Chroman-6-Yl) Diisopropylphosphoramidite is a high-purity, chiral phosphoramidite building block critical for the synthesis of complex oligonucleotides and other nucleoside derivatives. Its value lies in enabling the precise, automated solid-phase synthesis of modified RNA and DNA strands, which are essential for advanced research in pharmaceuticals, diagnostics, and molecular biology. This product is specifically designed for use by R&D scientists and process chemists in the biotechnology, pharmaceutical, and life science industries who require reliable, high-quality intermediates for oligonucleotide production.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated solid-phase synthesis of therapeutic and diagnostic oligonucleotides.
• Antisense & siRNA Therapeutics: For the production of chemically modified antisense oligonucleotides and small interfering RNA (siRNA) drug candidates.
• Aptamer Development: In the construction of nucleic acid aptamers used for target binding in diagnostic and therapeutic applications.
• Research & Development: As a critical reagent in academic and industrial labs for exploring novel nucleic acid chemistries and modifications.
• Probe & Primer Manufacturing: For creating labeled and modified DNA/RNA probes and primers used in PCR, sequencing, and hybridization assays.
• Pharmaceutical Intermediates: Serves as a sophisticated intermediate in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) based on nucleosides.

Basic Information

Product Name	2-Cyanoethyl((R)-2,5,7,8-Tetramethyl-2-((4R,8R)-4,8,12-Trimethyltridecyl)Chroman-6-Yl) Diisopropylphosphoramidite
CAS No.	1772522-16-3
Molecular Formula	C38H65N2O3P
Molecular Weight	628.91 g/mol
Synonyms	Tocopherol Phosphoramidite; Vitamin E Phosphoramidite; 2-Cyanoethyl N,N-diisopropylphosphoramidite of (R)-α-Tocopherol; (R)-2,5,7,8-Tetramethyl-2-((4R,8R)-4,8,12-Trimethyltridecyl)chroman-6-yl 2-Cyanoethyl Diisopropylphosphoramidite; α-Tocopherol Phosphoramidite; Toc-Phosphoramidite; Toc-CE Phosphoramidite; 6-O-(2-Cyanoethyl-N,N-diisopropylphosphoramidityl)-α-tocopherol
EINECS	Contact for details

Quality Control

Every batch of our 2-Cyanoethyl((R)-2,5,7,8-Tetramethyl-2-((4R,8R)-4,8,12-Trimethyltridecyl)Chroman-6-Yl) Diisopropylphosphoramidite is manufactured and tested under strict quality management systems. We ensure high purity and chiral integrity through comprehensive analytical methods including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Diastereomeric Purity	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.