Description

Fosnetupitant CAS NO 1703748-89-3 is a high-purity, advanced pharmaceutical intermediate. This compound is critical for the synthesis of netupitant, a key active pharmaceutical ingredient (API) used in antiemetic medications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of treatments for chemotherapy-induced nausea and vomiting (CINV). Our product is supplied with stringent quality control to ensure reliability and consistency in your synthesis processes.

Application

• Key intermediate in the synthesis of the neurokinin-1 (NK1) receptor antagonist, Netupitant.
• Critical raw material for the production of antiemetic combination drugs (e.g., Akynzeo®).
• Used in pharmaceutical R&D for developing next-generation nausea and vomiting prevention therapies.
• Essential for process chemistry and scale-up activities in API manufacturing.
• Reference standard for analytical method development and quality control in pharmaceutical labs.
• Building block for related chemical and pharmacological research.

Basic Information

Product Name	Fosnetupitant
CAS No.	1703748-89-3
Molecular Formula	C22H23F6N4O3P
Molecular Weight	512.41 g/mol
Synonyms	Fosnetupitant; Fosnetupitant (JAN/INN); (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-(4-methylpiperazin-1-yl)carbonylmorpholine 4-oxide phosphate; Netupitant phosphate prodrug; 1-[3,5-Bis(trifluoromethyl)phenyl]-N-{(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl}-N-methylmethanaminium phosphate; UNII-2GQ560LJ1P
EINECS	Contact for details

Quality Control

Our Fosnetupitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for pharmaceutical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.