Description

Gemfibrozil 1-o--Glucuronide-D6 is a high-purity, stable isotope-labeled internal standard critical for advanced analytical applications. This deuterated metabolite is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise quantification of gemfibrozil and its metabolites in complex biological matrices.

Application

• Quantitative Bioanalysis: Serves as an internal standard for the precise LC-MS/MS quantification of gemfibrozil and its glucuronide metabolite in plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug concentration-time profiles to determine absorption, distribution, metabolism, and excretion (ADME) parameters.
• Metabolite Profiling & Identification: Used as a reference standard in metabolite identification workflows to confirm the presence and quantity of the Phase II glucuronide conjugate.
• Method Development & Validation: Critical for developing and validating robust, GLP-compliant analytical methods in regulatory submissions.
• Doping Control & Forensic Analysis: Supports accurate detection and quantification of gemfibrozil and related compounds in specialized testing scenarios.
• Clinical Research: Facilitates reliable data generation in clinical trials studying gemfibrozil's efficacy, safety, and drug-drug interactions.

Basic Information

Product Name	Gemfibrozil 1-o--Glucuronide-D6
CAS No.	1703747-47-0
Molecular Formula	C23H28D6O8
Molecular Weight	~456.5 g/mol
Synonyms	Gemfibrozil D6 Glucuronide; Gemfibrozil 1-O-β-D-Glucuronide-d6; 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic Acid 1-O-β-D-Glucuronide-d6; Deuterated Gemfibrozil Glucuronide; Gemfibrozil Glucuronide Internal Standard-d6; Lopid Metabolite-d6; CI-719 Glucuronide-d6
EINECS	Contact for details

Quality Control

Every batch of Gemfibrozil 1-o--Glucuronide-D6 is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic techniques, to ensure compliance with industry standards for isotopic purity and chemical identity. Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic enrichment, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D6)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.