Description

D-α-Hydroxyglutaric Acid-13C5 Disodium Salt is a high-purity, isotopically labeled chemical standard essential for advanced analytical research and metabolic studies. This compound serves as a critical internal standard and tracer for the precise quantification and pathway analysis of D-2-hydroxyglutarate, a key oncometabolite. It is primarily required by research institutions, pharmaceutical developers, and diagnostic laboratories engaged in metabolomics, cancer research, and inborn errors of metabolism diagnostics.

Application

• Mass Spectrometry Internal Standard: Used for the accurate quantification of D-2-hydroxyglutarate (D-2HG) in biological matrices via LC-MS/MS, correcting for matrix effects and instrument variability.
• Metabolomic Pathway Tracing: Enables the study of glutamine metabolism, TCA cycle alterations, and the role of D-2HG in cancers such as glioma and AML (Acute Myeloid Leukemia).
• Diagnostic Assay Development: Critical for calibrating clinical diagnostic kits used to detect D-2HG-related disorders, including D-2-hydroxyglutaric aciduria and IDH-mutant tumors.
• Pharmaceutical Research: Supports drug discovery programs targeting Isocitrate Dehydrogenase (IDH) enzymes by providing a labeled standard for inhibitor screening and pharmacodynamic biomarker analysis.
• Biochemical Research: Facilitates in-vitro enzyme activity assays for IDH1 and IDH2, helping to elucidate kinetic parameters and mutant enzyme behavior.
• Quality Control Reference: Serves as a certified reference material (CRM) for ensuring the accuracy and reproducibility of analytical methods in contract research organizations (CROs).

Basic Information

Product Name	D-α-Hydroxyglutaric Acid-13C5 Disodium Salt
CAS No.	1648909-80-1
Molecular Formula	13C5H6Na2O5
Molecular Weight	Contact for details
Synonyms	(2R)-2-Hydroxypentanedioic-13C5 Acid Disodium Salt; D-2-Hydroxyglutaric-13C5 Acid Disodium Salt; (R)-2-Hydroxyglutaric-13C5 Acid Disodium Salt; D-2-HG-13C5 Disodium Salt; Sodium D-2-hydroxyglutarate-13C5; D-α-Hydroxyglutarate-13C5 Disodium; Isotopically Labeled D-2HG Standard; 13C5-Labeled D-2-Hydroxyglutarate
EINECS	Contact for details

Quality Control

Every batch of D-α-Hydroxyglutaric Acid-13C5 Disodium Salt is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR (1H, 13C) for structural confirmation and isotopic enrichment analysis by mass spectrometry. Certificates of Analysis (COA) detailing purity, assay, and specific tests are provided to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.