Description

Acid-Peg13-Nhs Ester CAS NO 1643594-31-3 is a heterobifunctional polyethylene glycol (PEG) linker featuring a carboxylic acid group and an N-hydroxysuccinimide (NHS) ester. This compound is engineered to facilitate the stable and efficient conjugation of biomolecules, such as peptides, proteins, and oligonucleotides, to surfaces or other molecules. It is an essential reagent for researchers and manufacturers in the fields of bioconjugation, drug delivery system development, and advanced material science.

Application

• Bioconjugation Reagent: For creating stable amide bonds between amine-containing biomolecules (proteins, antibodies, peptides) and carboxylated surfaces or other molecules.
• PEGylation Chemistry: Used to introduce hydrophilic PEG spacers to drugs, proteins, or nanoparticles to improve solubility, reduce immunogenicity, and enhance circulation time.
• Drug Delivery Systems: A key building block in the synthesis of antibody-drug conjugates (ADCs), polymer-drug conjugates, and targeted nanoparticle formulations.
• Surface Functionalization: For modifying biosensor chips, microarray slides, and other diagnostic platforms with specific biomolecular probes.
• Crosslinking Agent: In the preparation of hydrogels, polymer networks, and biomaterials with tailored properties for tissue engineering and 3D cell culture.
• Diagnostic Reagent Synthesis: Used in the development of fluorescently labeled probes, enzyme conjugates, and other reagents for immunoassays and molecular diagnostics.

Basic Information

Product Name	Acid-Peg13-Nhs Ester
CAS No.	1643594-31-3
Molecular Formula	C33H59NO17
Molecular Weight	741.82 g/mol
Synonyms	15-Aza-3,6,9,12-tetraoxapentacosanoic acid, 25-oxo-2,5,8,11,14,17,20,23-octaoxa-15-azapentacosan-1-oic acid 25-[(2,5-dioxo-1-pyrrolidinyl) ester]; α-Acid-ω-NHS-PEG13; HOOC-PEG13-NHS ester; Carboxy-PEG13-NHS ester; NHS-PEG13-acid; NHS-PEG13-COOH; 15-Amino-4,7,10,13-tetraoxahexadecanoic acid N-hydroxysuccinimide ester PEGylated acid; Heterobifunctional PEG linker, Acid/NHS
EINECS	Contact for details

Quality Control

Our Acid-Peg13-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and mass spectrometry for identity verification. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing the results against our stringent in-house specifications to ensure batch-to-batch consistency and reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.