Description

Gemcitabine Diphosphate Choline is a novel, high-purity nucleotide analog derivative designed for advanced pharmaceutical research and development. This compound is critical for synthesizing targeted prodrugs and exploring new therapeutic mechanisms in oncology. It is primarily utilized by pharmaceutical manufacturers, biotechnology research institutions, and academic laboratories focused on developing next-generation cancer treatments and novel drug delivery systems.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the synthesis of novel gemcitabine-based prodrugs and conjugates.
• Oncology Research: Used in preclinical and clinical research to study enhanced cellular uptake and targeted delivery mechanisms for cancer chemotherapy.
• Drug Delivery System Development: A critical component in the formulation of liposomal, nanoparticle, or other advanced carrier systems designed to improve therapeutic efficacy and reduce side effects.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and DNA synthesis pathways.
• Process Development & Scale-Up: Used by process chemists to develop and optimize scalable synthetic routes for new chemical entities (NCEs).

Basic Information

Product Name	Gemcitabine Diphosphate Choline
CAS No.	1643126-46-8
Molecular Formula	C₁₈H₃₂N₆O₁₃P₃
Molecular Weight	657.39 g/mol
Synonyms	Gemcitabine Choline Diphosphate; Choline Gemcitabine Diphosphate; 2'-Deoxy-2',2'-difluorocytidine-5'-(choline diphosphate); GEM-DP-Choline; Gemcitabine 5'-(choline diphosphate) salt; Gemcitabine-CDP-choline; Lipid-conjugated gemcitabine precursor; Cytidine, 2'-deoxy-2',2'-difluoro-, 5'-(ester with (2-hydroxyethyl)trimethylammonium diphosphate)
EINECS	Contact for details

Quality Control

Our Gemcitabine Diphosphate Choline is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with client specifications and current industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.