Description

9-Azido-Neu5Daz is a chemically modified sialic acid derivative, specifically designed as a versatile bioorthogonal reagent for advanced biochemical research and development. This compound is critical for enabling site-specific labeling and conjugation strategies in complex biological systems, such as cell surface glycan engineering and proteomic studies. It is an essential tool for researchers and developers in the fields of glycobiology, chemical biology, and pharmaceutical development, particularly for those working on targeted drug delivery systems and diagnostic probes.

Application

• Glycan Labeling and Imaging: Used in metabolic oligosaccharide engineering (MOE) to label cell-surface sialic acids with an azido handle for subsequent bioorthogonal click chemistry conjugation with fluorescent dyes or other probes.
• Chemical Biology Probes: Serves as a key precursor for synthesizing sialic acid-based probes to study sialyltransferase activity, glycan biosynthesis pathways, and host-pathogen interactions.
• Bioconjugation and ADC Development: Enables the site-specific modification of antibodies, proteins, and nanoparticles for the development of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Diagnostic Assay Development: Utilized in the creation of sensitive diagnostic tools and biosensors that leverage the specific reactivity of the azide group for signal amplification.
• Materials Science: Applied in the surface functionalization of biomaterials and hydrogels to introduce bioactive carbohydrate motifs for tissue engineering and cell culture applications.
• Virology and Vaccine Research: Used to study and modulate influenza virus hemagglutinin binding and other viral recognition processes involving sialic acids.

Basic Information

Product Name	9-Azido-Neu5Daz
CAS No.	1639411-87-2
Molecular Formula	C11H17N5O8
Molecular Weight	347.28 g/mol
Synonyms	9-Azido-5-acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid; 9-Azido-N-acetylneuraminic acid; 9-Azido-Neu5Ac; 9-Azido sialic acid; 5-Acetamido-9-azido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid; Azido-modified Neu5Ac; N-Acetyl-9-azidoneuraminic acid
EINECS	Contact for details

Quality Control

Our 9-Azido-Neu5Daz is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC, NMR, and MS, are validated to provide reliable specifications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.