Description

C[A(2',5')Ps[Rp]-A(3',5')Ps[Rp]] / Rp,Rp-2'3'-C-Diampss CAS NO 1638750-95-4 is a sophisticated, non-hydrolyzable cyclic dinucleotide analog, specifically designed as a potent and selective antagonist of the STING (Stimulator of Interferon Genes) pathway. This compound matters because it provides researchers with a critical tool for precisely inhibiting cGAS-STING signaling, a key mediator of innate immune response and inflammation, enabling groundbreaking studies in immunology, oncology, and autoimmune disease research. It is essential for pharmaceutical R&D teams, academic laboratories, and biotech companies focused on developing next-generation therapeutics targeting inflammatory diseases and improving the understanding of immune regulation.

Application

• STING Pathway Research: Serves as a high-purity reference standard and active inhibitor in fundamental biochemical and cellular studies of the cGAS-STING signaling axis.
• Immunology & Inflammation Studies: Used to elucidate the role of STING in various autoimmune disorders (e.g., lupus, Aicardi-Goutières syndrome) and sterile inflammatory conditions.
• Oncology Research: Employed to investigate the tumor microenvironment and the dual role of STING in both promoting anti-tumor immunity and supporting tumor progression under certain conditions.
• Drug Discovery & Development: Acts as a crucial pharmacological tool for screening and validating new drug candidates aimed at modulating the STING pathway for therapeutic benefit.
• Virology & Infectious Disease Models: Utilized in research to understand host defense mechanisms against viral infections where the cGAS-STING pathway plays a pivotal role.
• Biochemical Assay Development: Provides a reliable standard for developing and calibrating high-throughput screening (HTS) assays and other diagnostic tools targeting STING activity.

Basic Information

Product Name	C[A(2',5')Ps[Rp]-A(3',5')Ps[Rp]] / Rp,Rp-2'3'-C-Diampss
CAS No.	1638750-95-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Rp,Rp-c-di-AM(PS)2; Rp,Rp-2',3'-cGAMP(PS)2; Rp,Rp-cyclic di-AMP(S); STING antagonist C-59; Rp,Rp-2'-3'-cyclic diAMPS; Rp,Rp-2',3'-cGAMP phosphorothioate; Rp,Rp-2',3'-CDA(PS)2; Non-hydrolyzable STING inhibitor
EINECS	Contact for details

Quality Control

Our C[A(2',5')Ps[Rp]-A(3',5')Ps[Rp]] / Rp,Rp-2'3'-C-Diampss is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (typically ≥95% by HPLC), to ensure consistency and compliance with research-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and support your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store under an inert atmosphere or desiccated conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.