Description

Gemcitabine Monophosphate is a key nucleotide analog intermediate, specifically the monophosphorylated derivative of the potent chemotherapeutic agent Gemcitabine. This compound is critical for pharmaceutical research and development, serving as a direct precursor in the synthesis of active metabolites. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in oncology drug development, prodrug synthesis, and biochemical studies of nucleoside metabolism.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A crucial building block in the synthesis of Gemcitabine-based chemotherapeutic drugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action, resistance, and metabolism of nucleoside analogs.
• Prodrug Development: Serves as a key starting material for the design and synthesis of novel prodrugs aimed at improving bioavailability and targeting.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and quality assurance (QA) laboratories for HPLC, LC-MS, or NMR method development and validation.
• Biochemical Reagent: Utilized in enzymatic studies and as a substrate for kinases in research on nucleotide metabolism pathways.

Basic Information

Product Name	Gemcitabine Monophosphate
CAS No.	1638288-31-9
Molecular Formula	C9H12F2N3O7P
Molecular Weight	343.18 g/mol
Synonyms	2'-Deoxy-2',2'-difluorocytidine monophosphate; dFdCMP; Gemcitabine 5'-Monophosphate; 1-(2-Deoxy-2,2-difluoro-D-erythro-pentofuranosyl)-4-amino-2(1H)-pyrimidinone 5'-monophosphate; GEM-MP; (2R,3R,4R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-3,4-difluoro-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate
EINECS	Contact for details

Quality Control

Our Gemcitabine Monophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, residual solvents, and water content. Our quality commitment supports applications requiring high standards, including GMP-grade intermediates for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.