Description

1-(1,2R-Dihexadecanoylphosphatidyl)Inositol-3,4,5-Triphosphate, Hexasodium Salt is a high-purity, synthetic phospholipid derivative of inositol triphosphate, a critical secondary messenger in cellular signaling pathways. This compound is essential for advanced biochemical research, particularly in studying phosphoinositide-mediated signal transduction, membrane dynamics, and intracellular calcium release. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on cell biology, neurobiology, and drug discovery for metabolic and neurological disorders.

Application

• Biochemical Research Reagent: Used as a key substrate or standard in enzymatic assays to study the activity of phospholipase C (PLC) and phosphoinositide kinases.
• Cell Signaling Studies: Investigates the role of phosphatidylinositol (3,4,5)-trisphosphate (PIP3) in cellular processes such as proliferation, survival, and cytoskeletal reorganization.
• Liposome & Membrane Model Systems: Incorporated into artificial lipid bilayers or liposomes to mimic specific membrane compositions for biophysical and pharmacological studies.
• Drug Discovery & Screening: Serves as a critical tool in high-throughput screening (HTS) campaigns targeting the PI3K/Akt/mTOR signaling pathway for oncology and metabolic disease therapeutics.
• Neuroscience Research: Applied in studies of synaptic transmission, neuronal development, and the molecular mechanisms underlying neurological diseases.
• Reference Standard: Acts as an analytical standard for the quantification and identification of phosphoinositides in complex biological samples using techniques like mass spectrometry.

Basic Information

Product Name	1-(1,2R-Dihexadecanoylphosphatidyl)Inositol-3,4,5-Triphosphate, Hexasodium Salt
CAS No.	1628353-02-5
Molecular Formula	C47H81Na6O22P4
Molecular Weight	~1240.0 g/mol (Contact for exact weight)
Synonyms	PIP3 (16:0/16:0), Hexasodium Salt; Dipalmitoyl Phosphatidylinositol (3,4,5)-Trisphosphate; PI(3,4,5)P3 (dipalmitoyl); 1,2-Dihexadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-trisphosphate) Hexasodium Salt; Phosphatidylinositol 3,4,5-trisphosphate (DPPI); DPPI(3,4,5)P3; 1,2-Dipalmitoylphosphatidylinositol-3,4,5-trisphosphate; L-α-Phosphatidylinositol-3,4,5-trisphosphate (dipalmitoyl)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research-grade biochemicals. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and structural integrity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We adhere to a strict quality management system to ensure batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform/methanol/water mixtures
Water Content (KF)	≤ 3.0%
Sodium Content	~6 eq (by calculation)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.