Description

Propargyl-PEG8-CH2CH2COOH is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a terminal alkyne (propargyl) group and a carboxylic acid. This compound is specifically engineered for bioconjugation and click chemistry applications, offering a controlled-length, hydrophilic spacer. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, functionalized linkers for drug delivery systems, diagnostic probes, and biomaterial surface modification. Its precise structure enables the stable attachment of biomolecules under mild, aqueous conditions.

Application

• Bioconjugation Reagent: Used to covalently link peptides, proteins, antibodies, or oligonucleotides to other molecules, surfaces, or nanoparticles via its alkyne and carboxylate functional groups.
• Click Chemistry Substrate: The terminal propargyl group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) for highly specific and efficient labeling and coupling reactions.
• ADC (Antibody-Drug Conjugate) Development: Serves as a critical component in the synthesis of linker-payload constructs for targeted cancer therapies, providing solubility and reducing aggregation.
• PEGylation Agent: Used to modify therapeutic proteins and peptides to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Diagnostic Probe Synthesis: Facilitates the creation of fluorescent, radioactive, or other tagged probes for imaging and diagnostic assays.
• Hydrogel and Biomaterial Functionalization: Incorporated into polymer networks to introduce bio-reactive sites for cell adhesion or controlled drug release.
• Surface Modification: Used to create functionalized coatings on chips, sensors, or chromatography media for biosensing and separation applications.

Basic Information

Product Name	Propargyl-PEG8-CH2CH2COOH
CAS No.	1613752-50-3
Molecular Formula	C27H50O13
Molecular Weight	582.68 g/mol
Synonyms	Propargyl-PEG8-acid; 2,5,8,11,14,17,20,23-Octaoxapentacos-24-yn-1-oic acid; α-Propargyl-ω-carboxy octaethylene glycol; 3,6,9,12,15,18,21,24-Octaoxahexacos-25-ynoic acid; Propargyl-O-(CH2CH2O)8-CH2CH2COOH; Alkyne-PEG8-acid; 8-Arm PEG Alkyne (Acid Terminated); Propargyl PEG Acid (n=8)
EINECS	Contact for details

Quality Control

Our Propargyl-PEG8-CH2CH2COOH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep containers tightly sealed in a dry, inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms (M+Na+ ~605)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.