Description

(3R,4S)-(4-Hydroxy-Pyrrolidin-3-Yl)-Carbamic Acid tert-Butyl Ester is a high-purity, stereochemically defined chiral building block of significant importance in modern pharmaceutical synthesis. This compound serves as a critical intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel bioactive compounds.
• Peptidomimetic Development: The pyrrolidine scaffold is valuable for creating peptidomimetics and constrained analogs to improve metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical transformations.
• API Process Development: Serves as a starting material or intermediate in the scale-up and commercial route development for new chemical entities.
• Bioconjugation & Probe Synthesis: The functional groups allow for further derivatization, useful in creating chemical probes for biological target identification.

Basic Information

Product Name	(3R,4S)-(4-Hydroxy-Pyrrolidin-3-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	1613023-55-4
Molecular Formula	C9H18N2O3
Molecular Weight	202.25 g/mol
Synonyms	tert-Butyl (3R,4S)-4-hydroxypyrrolidine-3-carbamate; (3R,4S)-3-[(tert-Butoxycarbonyl)amino]-4-hydroxypyrrolidine; N-Boc-(3R,4S)-4-Hydroxy-3-aminopyrrolidine; (3R,4S)-1-Boc-4-Hydroxy-3-aminopyrrolidine; (3R,4S)-4-Hydroxy-3-(Boc-amino)pyrrolidine; (3R,4S)-3-(tert-Butoxycarbonylamino)-4-hydroxypyrrolidine; (3R,4S)-4-Hydroxy-Pyrrolidin-3-Yl-Carbamic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our (3R,4S)-(4-Hydroxy-Pyrrolidin-3-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure compliance with high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.