Description

Mal-Peg6-Pfp CAS NO 1599486-33-5 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a maleimide group at one terminus and a pentafluorophenyl (Pfp) ester at the other. This compound is a critical reagent for the site-specific conjugation of biomolecules, enabling the creation of stable, well-defined bioconjugates. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceutical development, advanced drug delivery systems, and diagnostic assay design.

Application

• Antibody-Drug Conjugate (ADC) Linker: For the controlled attachment of cytotoxic payloads to monoclonal antibodies via the maleimide-thiol chemistry.
• PEGylation of Peptides and Proteins: To modify therapeutic biomolecules with a hydrophilic PEG spacer, improving solubility, stability, and pharmacokinetic profiles.
• Surface Functionalization: For immobilizing biomolecules onto nanoparticles, biosensors, or chromatographic resins through the reactive Pfp ester group.
• Crosslinking Agent: In the synthesis of hydrogels or polymer networks for controlled release applications.
• Diagnostic Probe Synthesis: Conjugating fluorescent dyes or other reporter molecules to targeting ligands (e.g., peptides, antibodies).
• Bioconjugation Tool in Research: A versatile reagent for creating custom protein-protein or protein-small molecule conjugates in academic and industrial R&D.

Basic Information

Product Name	Mal-Peg6-Pfp
CAS No.	1599486-33-5
Molecular Formula	C33H45F5N2O11
Molecular Weight	740.72 g/mol
Synonyms	Maleimide-PEG6-PFP ester; 3-Maleimidopropanoic acid, 2,5-dioxo-1-pyrrolidinyl ester, polymer-bound; PFP-PEG6-MAL; Pentafluorophenyl-PEG6-maleimide; 2,5-Dioxopyrrolidin-1-yl 3-(2-{2-[2-(2-{2-[2-(2,3,4,5,6-pentafluorophenoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethylamino)-3-oxopropyl)maleamate; 6-Amino-3-oxapentanoic acid, N-[3-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)acetyl]amino]propyl]-, 2,3,4,5,6-pentafluorophenyl ester; MAL-PEG6-O-PFP; Heterobifunctional PEG crosslinker, MAL-PEG6-PFP.
EINECS	Contact for details

Quality Control

Our Mal-Peg6-Pfp is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for sensitive bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.