Description

Sp-8-Bromo-Cyclic Amps (Sodium Salt) is a high-purity, cell-permeable analog of cyclic adenosine monophosphate (cAMP) specifically engineered for biological research. This compound is a crucial pharmacological tool for the selective and potent activation of protein kinase A (PKA) signaling pathways in cellular systems. It is primarily utilized by researchers and scientists in the fields of neurobiology, cardiovascular research, and metabolic studies to investigate intracellular signal transduction mechanisms.

Application

• Biochemical Research: As a potent and selective activator of Protein Kinase A (PKA) for studying cAMP-mediated signaling cascades.
• Neuroscience Studies: Investigation of synaptic plasticity, neurotransmitter release, and neuronal excitability in model systems.
• Cardiovascular Pharmacology: Research into cardiac contractility, ion channel regulation, and vascular smooth muscle function.
• Cell Biology Assays: Used in cell-based assays to probe the role of PKA in cell proliferation, differentiation, and apoptosis.
• Drug Discovery Screening: Serves as a reference compound and positive control in high-throughput screening for modulators of the cAMP/PKA pathway.
• Metabolic Research: Studying the regulation of glycogen, lipid, and glucose metabolism in liver, muscle, and adipose tissues.

Basic Information

Item	Details
Product Name	Sp-8-Bromo-Cyclic Amps (Sodium Salt)
CAS No.	1573115-90-8
Molecular Formula	C10H11BrN5NaO6P
Molecular Weight	438.09 g/mol
Synonyms	Sp-8-Bromo-cAMPS sodium salt; 8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Sp-isomer, sodium salt; (SP)-8-Bromo-cyclic adenosine 3',5'-monophosphorothioate sodium salt; 8-Br-cAMPS-Sp; Sp-8-Br-cAMPS; Sp-8-Bromo-cyclic adenosine monophosphorothioate sodium salt; cAMP analog, PKA activator
EINECS	Contact for details

Quality Control

Our Sp-8-Bromo-Cyclic Amps (Sodium Salt) is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is subjected to comprehensive analytical testing, including HPLC for purity verification and structural confirmation by NMR and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.